Systems integration of innate and adaptive immunity
نویسندگان
چکیده
منابع مشابه
Bridging Innate and Adaptive Immunity
The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunology, the evolutionarily ancient innate immune response and modern adaptive immunity.
متن کاملLinkages of innate and adaptive immunity.
The innate immune system is activated by pathogens or environmental antigens following their binding by recognition molecules such as mannan-binding lectin, C-reactive protein and the mannose receptor. Natural antibody, which represents a collection of germline-encoded antigen recognition molecules, is also important in recognition of pathogens and activation of the innate immune system via the...
متن کاملHistamine regulation of innate and adaptive immunity.
Histamine influences many cell types involved in the regulation of innate and adaptive immune responses including antigen-presenting cells (APCs), Natural Killer (NK) cells, epithelial cells, T lymphocytes and B lymphocytes. These cells express histamine receptors (HRs) and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturati...
متن کاملAdjuvants of Immunity: Harnessing Innate Immunity to Promote Adaptive Immunity
Since Jules Freund reported that crude mycobacterial extracts greatly promoted immune responses to antigens (1), the use of adjuvants has become a widespread, but poorly understood practice to promote T and B cell responses (2). Recent studies have begun to identify the chemical nature of several adjuvants and the cellular and molecular mechanisms of their long-elusive immunologi-cal effects. F...
متن کاملSystems biology and innate immunity.
use of systems biology approaches to better understand innate immunity. Inflammatory disorders or syndromes are readily amenable to investigation by systems biology approaches, largely because an extensive repertoire of antibodies, reagents and assays exists for the evaluation of inflammatory cells and molecules. Moreover, inflammatory disorders often have systemic sequelae such as changes in a...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2015
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2015.05.098